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Arulkumaran, K. S. G.
- Phytosomes-An Advanced Herbal Technology
Authors
1 Department of Pharmaceutics, KMCH College of Pharmacy, Coimbatore-641 048, Tamil Nadu, IN
2 KMCH College of Pharmacy, Coimbatore-48, Tamil Nadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 5 (2011), Pagination: 191-194Abstract
The term "Phyto" means plant while "some" means cell-like. Phytosome are little cell like structure. This is an advanced herbal delivery system which contains the bioactive phytoconstituents of herb extract surrounds and bound by Phospholipids. The potential uses of large number of herbal drugs are limited due to their poor absorption and poor bioavailability after oral administration. Phytosomes exhibit better pharmacokinetic and pharmacodynamic profile than conventional herbal extracts. Phytosome technology has been effectively used to enhanced the bioavailability of many popular herbal extracts including milk thistle, ginkgo biloba, grape seed, green tea, hawthorn, ginseng etc, and can be developed for various therapeutic uses or dietary suppliments. The phospholipid molecular structure includes a water soluble head and two fat soluble tails, because of this dual solubility the phospholipid acts as an effective emulsifier which is also one of the chief components of the membranes in our cells.Keywords
Phytosomes, Phospholipids, Herbal Extracts, Bioavailability.- Insilico Evaluation of Inhibitory Profiles of Phytochemicals for ACC Domains
Authors
1 KMCH College of Pharmacy, Coimbatore, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 2 (2011), Pagination: 308-312Abstract
Evaluating acetyl-CoA carboxylase (ACC) as the target enzyme for the treatment of hyperlipidemia can lead to the detection of new inhibitors that can potentially be optimized as lipid lowering agents and could also form a novel method of screening a large number of plant constituents. Inhibition of ACC2 may prevent lipid-induced insulin resistance and type 2 diabetes, making the enzyme an attractive pharmaceutical target. The crystal structures of the biotin carboxylase (BC) domain of human ACC2 (PDB ID: 3GLK) and carboxyl transferase (CT) domain of human ACC2 (PDB ID: 3FF6) have been selected for molecular targets for Insilico studies of some potent phytochemicals like hydroxycitric acid, terrestrosin, forskolin and EGC. The interactions between the compounds and crystal structures of the enzymes have been performed using Accelrys Discovery Studio 2.1 Ligandfit protocol. Findings from the docking procedure indicate different binding modes of the compounds , further more the studies reveal that EGC was found to be a ideal inhibitor for both ACC2 Domains, thus can be suggested as a better inhibitor for lipid lowering .